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1 edition of Azaheterocycles Based on α, β-Unsaturated Carbonyls found in the catalog.

Azaheterocycles Based on α, β-Unsaturated Carbonyls

Valentin A. Chebanov

Azaheterocycles Based on α, β-Unsaturated Carbonyls

by Valentin A. Chebanov

  • 72 Want to read
  • 35 Currently reading

Published by Springer-Verlag Berlin Heidelberg in Berlin, Heidelberg .
Written in English

    Subjects:
  • Biochemistry,
  • Organic Chemistry

  • Edition Notes

    Statementby Valentin A. Chebanov, Sergey M. Desenko, Thomas W. Gurley
    ContributionsDesenko, Sergey M., Gurley, Thomas W. (Thomas Wood), SpringerLink (Online service)
    The Physical Object
    Format[electronic resource] /
    ID Numbers
    Open LibraryOL25569104M
    ISBN 109783540683612, 9783540683674

    Three-membered Azaheterocycles Based on α,β-Unsaturated Ketones // Current Organic Chemistry, , 12, – Chebanov V.A., Desenko S.M. Dihydroazines Based on α,β-Unsaturated Ketones Reactions // Current Organic Chemistry, , 10, The Wolff–Kishner reduction is a reaction used in organic chemistry to convert carbonyl functionalities into methylene the context of complex molecule synthesis, it is most frequently employed to remove a carbonyl group after it has served its synthetic purpose of activating an intermediate in a Organic Chemistry Portal: wolff-kishner-reduction.

    Introduction. α,β‐Unsaturated carbonyl compounds are widely distributed in food (Götz‐Schmidt et al., ; Boelens and van Gemert, ; Feron et al., ).They are naturally formed in fruits and vegetables as a result of enzymatic and/or spontaneous lipid by: In my book it is suggested that in order to add alkyl groups in α,β-unsaturated carbonyl compounds we use organometallic reagents such as organolithium reagents. In the previous chapters it was suggested that the addition of alkyl groups in carbonyl compounds with saturated chains it is conducted by using secondary amines that produce enamines.

    Abstract. An efficient and room-temperature procedure is developed for high yield synthesis of novel α,β-unsaturated derivatives of thiopyran 3 directly from ketone 1 and various aldehydes in the presence of catalytic quantities of TMSNMe 2 and MgBr 2 ˙OEt 2 under solvent-free conditions. The main advantage of the procedure is that the formation of the undesired bis by-products is by: Addition of enamines to α, β-unsaturated carbonyls to produce 1,5-diketones. Ketones can be converted to enamines and used to alkylate α,β-unsaturated carbonyl compounds because enamines have a carbanion resonance form: The 3-step process results in formation of. 1,5-diketones (which are synthetically useful in cyclizations): Size: 1MB.


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Azaheterocycles Based on α, β-Unsaturated Carbonyls by Valentin A. Chebanov Download PDF EPUB FB2

Azaheterocycles Based on α, β-Unsaturated Carbonyls. Authors (view affiliations) Valentin A. Chebanov Search within book. Front Matter. Pages I-VII Five-Membered Azaheterocycles. Valentin A. Chebanov, Sergey M. Desenko, Thomas W. Gurley.

Pages Six-Membered Azaheterocycles Based on 1,3-Binucleophiles. Valentin A. Chebanov. Summary: "This monograph is devoted to heterocyclization of aliphatic and aromatic [alpha], [beta]-unsaturated carbonyls with various binucleophiles. These reactions produce partially Azaheterocycles Based on α nitrogen-containing heterocycles that are interesting due to their significant role in biological processes.

This book is devoted to heterocyclizations of aliphatic and aromatic, -unsaturated carbonyls with various binucleophiles leading to three- five- six and seven-membered partially hydrogenated nitrogen-containing heterocycles.

Abstract: The present review is devoted to heterocyclizations of α,β-unsaturated carbonyl compounds which result in the formation of three-membered partially hydrogenated nitrogen containing heterocyclic systems – aziridinyl ketones, biand tricyclic aziridines. Scientists are interested in these classes of heterocyclic compounds first of all by their photochromic properties and high sensitivity Cited by: 9.

Cite this chapter as: Chebanov V.A., Desenko S.M., Gurley T.W. () Three-Membered Azaheterocycles. In: Azaheterocycles Based on α, β-Unsaturated by: 1. This monograph is devoted to heterocyclization of aliphatic and aromatic α,β-unsaturated carbonyls with various binucleophiles.

These reactions produce partially hydrogenated nitrogen-containing. Synthesis, Antiproliferative, and Multidrug Resistance Reversal Activities of Heterocyclic α, β -Unsaturated Carbonyl Compounds.

Chemical Biology & Drug Design88 (4), DOI: /cbddCited by: Sixty-nine novel α,β-unsaturated carbonyl based compounds, including cyclohexanone, tetralone, oxime, and oxime ether analogs, were synthesized. The antiproliferative activity determined by using seven different human cancer cell lines provided a structure–activity by: Various heteroalkynes including ynol ethers, ynamides, and thioalkynes work well for this transformation, leading to the production of (E)‐α,β‐unsaturated esters, amides, and thioesters in moderate to excellent yields with good functional group compatibility.

It represents one of the rare examples of regio‐ and stereoselective Cited by: 5. α,β-Unsaturated Carbonyl Compounds:* In general, a compound that contains both a carbon-carbon double bond and a carbon-oxygen double bond has properties that are characteristic of both functional groups.

At the carbon-carbon double bond an unsaturated ester or unsaturated ketone undergoes electrophilic addition of acids and halogens, hydrogenation, hydroxylation,File Size: KB. Compounds containing the α,β-unsaturated carbonyl group (such as α,β-unsaturated ketones/aldehydes, esters, amides etc.) have been well known in the literature for their anticancer property and considered as one of the most important chemical structures in drug discovery [20,21].They are widely distributed in biologically active compounds that have been used successfully in cancer Author: Mohammad Hossain, Umashankar Das, Jonathan R.

Dimmock. Azaheterocycles Based on a,S-Unsaturated Carbonyls 作者: Chebanov, Valentin A./ Desenko, Sergey M./ Gurley, Thomas W. 出版社: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG 页数: 定价: 元 ISBN:   The discoveries that selenium and sulfur substituents could be easily introduced α to a variety of acidifying functional groups, and that these derivatives could be smoothly converted to olefins by selenoxide or sulfoxide syn elimination under mild conditions greatly broadened the range of α,β‐unsaturated carbonyl compounds that could be Cited by: 8.

Herein we report an effort to further optimize the previously described chalcone-based proteasome inhibitor 3,5-bis-(4-boronic acid-benzylidene)methyl-piperidinone (AM) 20 carrying an α,β-unsaturated carbonyl system and two boronic acid moieties, compound 1. In here, we describe the synthesis and the biological characterization of a Cited by: The titanium(iii)-catalysed cross-selective reductive umpolung of Michael-acceptors represents a unique direct conjugate β-alkylation reaction.

It allows the cross-selective preparation of 1,6- and 1,4-difunctionalised building blocks without the requirement of stoichiometric organometallic reagents. In Cited by:   A series of new α,β-unsaturated carbonyl-based cyclohexanone derivatives was synthesized by simple condensation method and all compounds were characterized by using various spectroscopic techniques.

New compounds were evaluated for their effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).Cited by:   This protocol describes a new approach for the preparation of α-allylated α,β-unsaturated carbonyl compound by chemoselective cross-coupling of Cited by: 6.

The Concept of Protecting Functional Groups during acetalizationof α,β-unsaturated ketones. Double bond increases the electron density at the carbonyl carbon in α,β-unsaturated ketone.

Chemoselectiveacetalizationof the ketogroup. ViaS,S-Acetals Since thioacetalsare quite stable toward hydrolysis, there is no special. Dihydroazines Based on α,β-Unsaturated Ketones Reactions Article in Current Organic Chemistry 10(3) February with 90 Reads How we measure 'reads'.

In the absence of the cells, the reaction of GSH with all α,β-unsaturated carbonyls produced only their corresponding adducts.

These results show that the GSH adducts of α,β-unsaturated aldehydes, CA and ACR, are quickly reduced by certain intracellular carbonyl reductase(s) and excreted from the cells, unlike the GSH adduct of α,β Cited by: 8.

The mild reaction conditions tolerate several functional groups including benzoate, tosylate, expoxide, and α,β-unsaturated carbonyls. Z. Ye, M. Dai, Org. Lett.,17, In a palladium-catalyzed intermolecular aminocarbonylation of alkenes, the use of hypervalent iodine reagent can accelerate the reaction.Reactions of carbonyl compounds with α,β-unsaturated nitriles as a convenient pathway to carbo- and heterocycles.

Yu A Sharanin 1, M P Goncharenko 1 and Victor P Litvinov 2 ©, Russian Academy of Sciences and Turpion Ltd Russian Chemical Reviews, Vol Number 5.Hydrogen bond induced reactivity and selectivity control in the 1-butylmethylimidazolium based ionic liquid catalysed reaction of thiols with α,β-unsaturated carbonyl compounds is reported with remarkable influence of the anion and the C-2 hydrogen in catalytic activity and reversal of selectivit.